02. May 2016

In this study, we first developed a modernized indentation technique for measuring tablet hardness. This technique is featured by rapid digital image capture, using a calibrated light microscope, and precise area-determination. We then systematically studied effects of key experimental parameters, including indentation force, speed, and holding time, on measured hardness of a very soft material, hydroxypropyl cellulose, and a very hard material, dibasic calcium phosphate, to cover a wide range...