04. July 2018

Monoclinic paracetamol (PA) is notorious as a poorly compactible model drug. Polyvinylpyrrolidone (PVP) is a polymer that can act as an effective binder to improve the mechanical properties of PA. It is surprising however that the role of mixing conditions on the physicochemical and mechanical properties of PA–PVP mixtures has not been reported previously. The results of this work showed that PA–PVP mixtures containing 5% (w/w) PVP prepared using high energy mixing conditions had...