13. January 2016

The aim of this study was to formulate a microparticulate delivery system to deliver cinnarizine (CIN) directly to its site of absorption to overcome its low oral bioavailability. Enteric microparticles were prepared by varying ratios of pH-sensitive polymers (Eudragit L100 and Eudragit S100). A full 33 factorial experimental design was adopted to evaluate the effect of variables (CIN concentration as well as Eudragit’s concentration) on the tested parameters, namely, particle size (p.s.),...