27. October 2016

Abstract Mucoadhesive in situ gelling systems (soluble gels) have received considerable attention recently as effective stimuli-transforming vectors for a range of drug delivery applications. Considering this fact, the present work involves systematic formulation development, optimization, functional evaluation and ex vivo performance of thermosensitive soluble gels containing dexamethasone 21-phosphate disodium salt (DXN) as the model therapeutic. A series of in situ gel-forming systems...

25. January 2016

Recently, we reported that intranasal vaccination of humans with whole inactivated influenza vaccine in the absence of mucosal adjuvant induced neutralizing antibody responses in the serum and nasal mucus. The mucoadhesive excipient carboxy-vinyl polymer (CVP) increases the viscosity and therefore mucoadhesiveness of intranasal medicaments and is an authorized excipient in Japan. In the present study, we analyzed the effect of adding CVP on intranasal whole inactivated influenza vaccine antigen...

10. July 2015

This article reports on the micro- and nanonization of meloxicam (MEL) with the aim of developing pre-dispersions as intermediates for the design of intranasal formulations. As a new approach, combined wet milling technology was developed in order to reduce the particle size of the MEL. More

21. February 2015

Animesh Kumar, Tarun Garg, Ganti S. Sarma, Goutam Rath, Amit Kumar Goyal, Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga 142001, Punjab, India Received 22 August 2014, Revised 29 December 2014, Accepted 26 January 2015, Available online 10 February 2015 http://www.sciencedirect.com/science/article/pii/S0928098715000305