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27. April 2015
Eur J Pharm Sci. 2015 Apr 20. pii: S0928-0987(15)00155-4. doi: 10.1016/j.ejps.2015.04.012. Lipocalin-type prostaglandin D synthase (L-PGDS), a member of the lipocalin superfamily, possesses the function of forming complexes together with various small lipophilic molecules. In this study, we chose telmisartan as a model drug due to its pH dependent poor water solubility, and developed and characterized a novel solubilized formulation of telmisartan using a complex formulation with L-PGDS......