28. July 2016

ABSTRACT Background: Gastroretentive floating microsphere containing Lafutidine, a second generation histamine H2–receptor antagonist were prepared by ionotropic gelation technique by using sodium alginate, HPMC K4M, ethyl cellulose as polymers, sodium bicarbonate as gas generating agent and calcium chloride as cross linking agent. Objective: To formulate a system to remain in the stomach for prolonged and predictable period in order to enhance the drug bioavailability. Method: They were...