14. June 2016
Abstract Lansoprazole degrades rapidly in an aqueous solution at low pH values. Degradation rate increases at pH values below 4 .The aim of this study was development of enteric coated pellets containing Lansoprazole by an extrusion/ spheronization technique. Eight different formulations based on lactose and six different formulations based on mannitol, consisting of different portions of other excipients including sucrose, hydroxy propyl methyl cellulose, magnesium carbonate, and sodium lauryl...
01. February 2016
We aimed to develop a suitable micropellet delivery system for Lansoprazole, a highly potent proton pump inhibitor and acid-unstable physiologically active anti-secretory compound. Although clinically manifested to be highly effective for treating acid reux-related diseases, poor water solubility and short gastric retention time, typically does not provide extended period of relief. Materials and method: Micropellets of the drug was prepared using ionotropic gelation technique, where gelation...