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14. September 2017
Solid dispersions of leflunomide with polymers are prepared by several methods.
Improved dissolution rate of leflunomide by solid dispersion approach is estimated.
Influence of the preparation method and polymer nature on the dissolution is revealed.
Solid dispersions for immediate and sustained release are proposed.
11. September 2017
Solid dispersions of leflunomide with polymers are prepared by several methods.
Improved dissolution rate of leflunomide by solid dispersion approach is estimated.
Influence of the preparation method and polymer nature on the dissolution is revealed.
Solid dispersions for immediate and sustained release are proposed.
13. February 2017
Abstract The objective of this study is to enhance the dissolution properties of leflunomide, a class BCS-II drug by incorporating the self emulsifying (SE) form of the drug onto liquisolid systems in the form of tablets. Different formulae were prepared by dissolving leflunomide in PEG300 then forming SE systems using tween 80 as surfactant and either sesame oil and paraffin oil then adsorbing on powder excipients to form SE liquisolid powders. The prepared powders showed adequate flowability....