03. February 2016

Objective: In the present study an effort was initiated to prepare alginate oating microparticles for oral delivery of levofloxacin. Methods: Alginate oating microparticles were prepared by ionotropic gelation method with calcium carbonate (CaCO ) 1% w/v in gelation medium used as gas-forming agent. Chitosan was used to improve the drug 3 encapsulation efciency. A number of physiochemical properties such as particle size, shape, in vitro buoyancy and drug releasewere comparedwith...