03. March 2018
The paper reports on the development of a numerical model for the simulation of a lyophilization process in a vial. Experimental analysis is presented of lyophilization dynamics inside a single vial in a laboratory scale lyophilizer. The problems of lyophilization modelling of a mannitol water solution are covered in detail. The effects of the small scale of the laboratory device with respect to a correct definition of boundary conditions for the numerical simulations are described, especially t
22. January 2018
Purdue University researchers and industry leaders are teaming up to transform the freeze-drying process, formally known as lyophilization, used to make everything from lifesaving drugs and biotech products to foods.
A consortium of researchers, industry members from pharmaceutical and food processing sectors, as well as equipment makers and others, are working together at the Advanced Lyophilization Technology Hub, or LyoHub, at Purdue to modernize a process that has not changed over decades.
26. June 2017
Most of the drug products available in the market are for oral drug administration. Oral route is preferred due to ease of administration, versatility, patient compliance and accurate dosing. However, oral administration is not suitable for people with dysphasia, a condition that results in difficulty in swallowing.
29. April 2017
The aim of this study was to develop oral lyophilisates with improved meloxicam (MEL) dissolution, optimizing each step of the preparation by design of experiments. First, meloxicam nanosuspensions were prepared by high-pressure homogenization (HPH), using PVP, Poloxamer or PEG as stabilizers and were subjected to freeze-drying using mannitol as cryoprotectant.
29. December 2016
Abstract Fast dissolving tablets (FDTs) have received more interest in the pharmaceutical industry for those categories of drug which show slow dissolution and less oral bioavailability. Nowadays various technologies have been developed for FDTs with improved patient compliance and convenience. FDTs tablets provide an advantage particularly for the pediatric and geriatric patients who have difficulty in swallowing and also for that who are travelling for a long and suffers from lack of water...
08. August 2016
Abstract Previously, it was shown in Phase I clinical trials that solubility-limited oral absorption of docetaxel and paclitaxel can be drastically improved with a freeze dried solid dispersion (fdSD). These formulations, however, are unfavorable for further clinical research because of limitations in amorphicity of SD and scalability of the production process. To resolve this, a spray drying method for an SD (spSD) containing docetaxel or paclitaxel and subsequently drug products were...
18. February 2015
ABSTRACT The present study describes the development of an orally disintegrating tablet containing a non-water-soluble drug delivery system. A model system was applied to evaluate the effect of different-sized particles on tablet characteristics. Cellets were incorporated into tablets prepared by freeze-drying from a 100 mg/mL mannitol or sucrose solution. Particle size distributions were 200–355 μm for Cellets 200 (C200) and 500–710 μm for Cellets 500 (C500). An examination of the...