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20. March 2017
Abstract Roflumilast (RFL), a newly approved and highly selective phosphodiesterase 4 inhibitor for the treatment of severe chronic obstructive pulmonary disease, associated with chronic bronchitis and a history of numerous exacerbations. The main objective of this work was to evaluate the simultaneous (TG/DSC) thermoanalytical characterization and compatibility of roflumilast with the widely used excipients for solid dosage form employing differential scanning calorimetry (DSC),...