06. October 2017
In the field of nasal drug delivery, among the preparations defined by the European Pharmacopoeia, nasal powders facilitate the formulation of poorly water-soluble active compounds. They often display a simple composition in excipients (if any), allow for the administration of larger drug doses and enhance drug diffusion and absorption across the mucosa, improving bioavailability compared to nasal liquids. Despite the positive features, however, nasal products in this form still struggle to...
27. July 2017
With the XStraw® drinking straw, a product innovation by the company DS-Technology GmbH, the intake of drugs is made incredibly easy and becomes more convenient for patients with swallowing difficulties and the elderly - because drinking with a straw is the most wonderful thing for little ones and grown-ups alike.
06. July 2017
Chitosan is a natural copolymer generally available in pharmaceutical and food powders associated with drugs, vitamins, and nutraceuticals.
29. May 2017
Chitosan and clays can form nanocomposites via electrostatic interactions, offering an interesting potential as advanced drug delivery systems. Such nanocomposites can be prepared in the form of microparticles using spray-drying
03. March 2017
Abstract Fenofibrate, a drug of fibrate class, is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. However, bioavailability of fenofibrate is often low and unpredictably due to its poor solubility. Microparticle entrapped micelles (MEM) technology is a novel method of incorporating surfactants in solid dosage form for improving in vitro and in vivo performance of poorly water soluble drugs. Increasing the fenofibrate solubility by MEM technology has not...
09. February 2017
Abstract The effects of propellant type, cosolvent content, and air humidity on the morphology and solid phase of the particles produced from solution pressurized metered dose inhalers containing the corticosteroid beclomethasone dipropionate were investigated. The active ingredient was dissolved in the HFA propellants 134a and 227ea with varying levels of the cosolvent ethanol and filled into pressurized metered dose inhalers. Inhalers were actuated into an evaporation chamber under controlled...
10. October 2016
Abstract Objectives The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs). Methods The moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric analysis. Microproperty/macroproperty assessment was investigated using atomic force...
16. May 2016
The development of Garlic as a commercial antibiotic has come to a halt. Although its efficiency is scientifically proven; it has only been used as dietary supplement or as traditional medicine. In this study we investigated the use of spray drying to obtain a powder which releases allicin, the most important antibiotic active compound in garlic. Alliin and alliinase, which serve as precursors for allicin production, were encapsulated separately into microspheres consisting of lactose as a...
10. March 2016
Purpose: To develop gastro-resistant multiparticles systems for mesalazine colon delivery capable to facilitate the dispersion in water and the intake by children. Method: Mesalazine microparticles, containing stearic acid, carnauba wax and Eudragit L®, were obtained by spray-congealing. “Excipient microparticles” of mannitol/lecithin were prepared by spray-drying. Mesalazine lipid microparticles, non-agglomerating per se, were agglomerated by blending in turbula with mannitol/lecithin...
03. February 2016
Objective: In the present study an effort was initiated to prepare alginate oating microparticles for oral delivery of levofloxacin. Methods: Alginate oating microparticles were prepared by ionotropic gelation method with calcium carbonate (CaCO ) 1% w/v in gelation medium used as gas-forming agent. Chitosan was used to improve the drug 3 encapsulation efciency. A number of physiochemical properties such as particle size, shape, in vitro buoyancy and drug releasewere comparedwith...