28. November 2017
Particle design via spherical agglomeration is a size enlargement technique used in various bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in which an immiscible bridging liquid is added to agglomerate crystals prior to deliquoring. Spherical agglomeration has the potential to dramatically simplify downstream processing, and improves the handling of difficult, needle-shaped crystals. This review consolidates the understanding of the controlling process...
09. February 2017
Abstract Computational modelling of twin-screw granulation was conducted by using an artificial neural network (ANN) approach. Various ANN configurations were considered with changing hidden layers, nodes and activation functions to determine the optimum model for the prediction of the process. The neural networks were trained using experimental data obtained for granulation of pure microcrystalline cellulose using a 12 mm twin-screw extruder. The experimental data were obtained for various...
23. December 2016
ABSTRACT Research in pharmaceutical process development has gained a lot of interest over the last years. Long development times, increasing R&D costs, increasing competition, and short patent duration are some of the driving forces for the increased research efforts in the field. Increased process understanding of the pharmaceutical process has resulted in major improvements in the field. Process systems engineering (PSE) approaches, which have been successfully applied in the design,...
22. July 2015
In this work, we studied crystallization kinetics of amorphous hesperetin (HRN) and naringenin (NRN) alone, and in 1:1 proportion with mannitol at Tg + 15 K. Crystallization rate of NRN was found to be significantly higher than HRN. Mannitol accelerated crystallization of HRN as well as NRN. NRN exhibited higher crystallization rate than HRN, in presence of mannitol, as well. More