11. September 2018

Oromucosal drug delivery is necessary when a local effect in the oral cavity is required. Bioadhesive formulations should be advantageous because a larger fraction of the active principal is retained at the site of action allowing for an enhanced and prolonged effect. Despite a variety of mucoadhesion test systems being described in literature, none of these in-vitro tests does relate to physiological conditions in the oral cavity and suites for the testing of complete dosage forms, e.g....

28. August 2018

This study described the rheological and mucoadhesive properties of one natural water-soluble polysaccharide from Bletilla striata (BSP). The rheological characteristics of BSP in aqueous solutions and BSP mixed with other polymers were investigated under various conditions, including concentration, temperature, pH, and salt addition. Viscometric studies and ex vivo mucoadhesion tests were also conducted to examine the mucoadhesive properties of BSP. Results indicated that BSP behaved as a...

25. August 2018

Chitosan is a cationic polysaccharide that exhibits mucoadhesive properties which allow it to adhere to mucosal tissues. In this work, we explored chemical modification of chitosan through its reaction with methacrylic anhydride to synthesise methacrylated derivative with the aim to improve its mucoadhesive properties. The reaction products were characterised using 1H NMR, FTIR and UV–Vis spectroscopy. 1H NMR and ninhydrin test were used to quantify the degree of methacrylation of chitosan....

30. May 2018

A novel delivery system based on self-assembled liposome from multi-layered fibrous mucoadhesive membrane has been developed to improve the bioavailability of Carvedilol (Car). This system consisted of an electrospun layer (enable self-assembly of liposome once contacting with water), an adhesive layer (prolong the retention period in the mouth) and a backing layer . SEM、 DSC and FTIR were applied to characterize the fiber. The TEM and fluorescence study demonstrated the formation of...

28. February 2018

This study aimed to formulate a solid dosage form as decongestant for intranasal application. Nine formulations (A-K) based on gelatin and other polymers were manufactured following the solvent evaporation method. Fabricated patches were characterized according to uniformity of weight, thickness, transparency and surface pH, tensile strength and elongation at break. Adhesiveness was assessed by tack test and bioadhesive assay on the nasal porcine mucosa. Naphazoline was incorporated in the diffe

18. January 2018

This work addresses the establishment and characterization of gellan gum:pectin (GG:P) biodegradable mucoadhesive beads intended for the colon-targeted delivery of resveratrol (RES). The impact of the polymer carrier system on the cytotoxicity and permeability of RES was evaluated. Beads of circular shape (circularity index of 0.81) with an average diameter of 914 μm, Span index of 0.29, and RES entrapment efficiency of 76% were developed.

18. November 2017

The objective of the present study was to develop rectal mucoadhesive hydrogels loaded with Tolmetin Sodium, a non-steroidal anti-inflammatory drug, for prolonged duration of action and increased bioavailability. Fourteen formulae were prepared with different types and concentrations of polymers as hydroxypropylmethyl cellulose, hydroxylethyl cellulose, carboxymethyl cellulose and sodium alginate. Each formulation contain Tolmetin Sodium equivalent to 5% w/w active drug. The effect of the...

10. November 2017

Mucoadhesive formulations are well known for the delivery of drugs via the mucosal membrane of oral (sub- lingual, buccal and gingival), rectum, nose, eyes, and vagi- na. Among the various drug delivery approaches, the buc- cal mucosa delivery system o ers several bene ts like easy accessibility, patient compliance, a relatively large surface area of absorption for drug molecules, reduced gastric ir- ritation and simple delivery devices.