15. March 2016

Thiocolchicoside used for the effective treatment of muscle spasm, cramps, musculoskeletal and neuromuscular disorders. It is available in market in the form of capsules and injection. The major problem associated with thiocolchicoside is it's bioavailability which is very low i.e. 25-30% only so in order to minimize drug loss due to first pass metabolism, and overcome problem associated with low bioavailability of drug there is a need to formulate semisolid preparation in the form of gel so we...