02. June 2018
Any imbalance in body's pH or temperature may alter immune response and lead to conditions such as autoimmune disorders, infectious diseases, cancer and diabetes. Dual pH and thermo-responsive carriers have been striving forward as next generation therapeutic medicines as they can intelligently trigger drug release in a stimuli responsive manner with minimal toxicity, improved therapeutic efficacy and reduced exposure to normal cells. Besides polymeric nanoparticles and polymeric micelles,...
25. June 2016
Abstract A facile controlled-release nanogels delivery system has been developed by using hydroxypropyl methylcellulose (HPMC) hybrid nanogels as encapsulation shell materials, which were synthesized by surfactant-free polymerization in aqueous solution. The effects of reaction time and cross-linker concentration on the size of the nanogels have been studied. The results showed that in a certain range, the particle size decreased with increasing reaction time and increasing concentration of...