24. May 2018

Oral drug administration remains the preferred approach for treatment of HIV in most patients. Maraviroc (MVC) is the first in class co-receptor antagonist, which blocks HIV entry into host cells. MVC has an oral bioavailability of approximately 33%, which is limited by poor permeability as well as affinity for CYP3A and several drug transporters. While once-daily doses are now the favoured option for HIV therapy, dose-limiting postural hypotension has been of theoretical concern when...

16. February 2018

Here you find some abstracts of Engineering of "Biomaterials for Drug Delivery Systems - beyond Polyethylene Glycol". 1 – PEGylated “stealth” nanoparticles and liposomes Through nanomedicine, game-changing methods are emerging to deliver drug molecules directly to diseased tissue. The targeted delivery of drugs and imaging agents via drug carrier-based platforms is among the most promising of these methods. Such drug delivery systems can now be synthesized from a wide range of different...

23. January 2018

Poloxamers, also known as Pluronics®, are block copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), which have an amphiphilic character and useful association and adsorption properties emanating from this. Poloxamers find use in many applications that require solubilization or stabilization of compounds and also have notable physiological properties, including low toxicity. Accordingly, poloxamers serve well as excipients for pharmaceuticals.