09. May 2016

The therapeutic potentials of silibinin – a phytochemical isolated from milk thistle plants – have not been fully realized due to its poor oral bioavailability caused by the low aqueous solubility. Existing solubility enhancement strategies of silibinin by nanonization were limited by their low payload. Herein we developed a supersaturating delivery system of silibinin exhibiting a high payload (≈ 76%) in the form of amorphous silibinin–chitosan nanoparticle complex (or silibinin...