28. February 2018

This study aimed to formulate a solid dosage form as decongestant for intranasal application. Nine formulations (A-K) based on gelatin and other polymers were manufactured following the solvent evaporation method. Fabricated patches were characterized according to uniformity of weight, thickness, transparency and surface pH, tensile strength and elongation at break. Adhesiveness was assessed by tack test and bioadhesive assay on the nasal porcine mucosa. Naphazoline was incorporated in the diffe