04. June 2018

In this study HPMC-eudragit based hydrodynamically balanced capsules of two model drugs; propranolol HCl and ofloxacin were prepared with the aim to have the gastric retention of the systems for longer periods of time with desired sustained/ controlled drug release. Methods Gastro-retentive capsules were prepared by simple physical blending of various low density polymers and filling into capsules. These capsules were subjected to in vitro buoyancy/ matrix integrity and dissolution studies....

09. April 2018

This chapter aims to preparation and in-vitro evaluation of ofloxacin floating tablets using different hydrophilic swelling polymers to localize the dosage form in the stomach in order to achieve gastric retention, and hence increase drug stability, sustainment and patient compliance leading to better treatment outcomes