15. September 2018
Both drug delivery performance and various age-related physical, mental and physiological changes can affect their effectiveness and safety in elderly patients. The many drug delivery systems developed over the years include recent novel transdermal, nasal, pulmonary and orally disintegrating tablet delivery systems that provide consistent, precise, timely and more targeted absorption. Certain drug delivery systems may be associated with suboptimal outcomes in the elderly because of the nature...
18. August 2018
Older adults with multimorbidity, polypharmacy, and complex health needs are the major consumer of health care. Ensuring that medicines are used safely, effectively, and delivered efficiently in this population is challenging. In this context, the approach to medicines delivery should seek to overcome some of the difficulties of delivering medicines to older people, and ensure each medication is delivered by the optimal and most convenient route for the patient in question. However, this poses...
10. July 2016
We previously prepared and pharmaceutically evaluated ginger orally disintegrating (OD) tablets, opti- mized the base formulation, and carried out a clinical trial in healthy adults in their 20s and 50s to measure their effect on salivary substance P (SP) level and improved swallowing function. In this study, we conducted clinical trials using the ginger OD tablets in older people to clinically evaluate the improvements in swallow- ing function resulting from the functional components of the...
30. June 2016
Abstract Age-related pharmacological changes complicate oral dosage form (ODF) suitability for older adults. The aim of this study was to investigate the appropriateness of ODF for older adults by determining the prevalence of ODF modifications in an aged care facility in Ireland. Drug charts for eligible patients were obtained. Details of all medications administered were recorded. ODF modifications were examined to determine if they were evidence-based: defined as complying with the product...
22. March 2016
An increasing elderly population is leading to a change in the global demographics. This presents a new challenge to society and the pharmaceutical industry. This demographic shift is providing an opportunity for the pharmaceutical industry to meet the specific needs of the changing patient population. One issue that has been identified is defining what is meant by “an older patient”, since this definition cannot be simply limited to chronological age. The fundamental purpose of the design...