14. August 2017
The potential for use of polymers in controlled drug delivery systems has been long recognized. Since their appearance in the literature, a wide range of degradable and non-degradable polymers have been demonstrated in drug delivery devices.
22. March 2017
Abstract: Background: Conventional dosage forms of neomycin sulphate suffer from different drawbacks like spillage, poor penetration, low bioavailability, etc. In situ ophthalmic gel can overcome these problems by improving bioavailability, decreasing spillage and diminish the need for recurrent application. Thus, the aim of the present work was to prepare and evaluate in situ ophthalmic gel of neomycin sulphate for sustained ocular delivery. Method: Two polymers, sodium alginate (0.2-0.7%) and...
17. November 2016
Abstract Most ophthalmic illnesses are treated by topical administration of drug in the form of conventional dosage forms (solutions, suspensions, or ointments). In spite of remarkable patient compliance, these dosage forms suffer from the issues of poor ocular bioavailability due to pathophysiological barriers prevailing in the eye. In recent decades, numerous efforts have been made to advance ophthalmic drug delivery including the one adopted to prolong the residence time of drug in the...
20. June 2016
Highlights • Ophthalmic viscoelastic devices (OVDs) were designed composed of HPC and ɩ-carrageenan (Carr). • The rheological and compressional properties of the polymer blends were characterised. • HPC and Carr were shown to physically interact in both dilute and gel states. • Binary platforms offered a wide range of rheological and compressional properties. • Platforms containing 3% HPC and 1% or 2% Carr exhibited properties advantageous for use as OVDs Read more...
07. June 2015
This study investigated the interaction between polydeoxyribonucleotide (PDRN) and several ionic and nonionic isotonic agents, thickeners and a preservative that were employed as excipients in ophthalmic preparations. Read More