22. March 2018

The Glatt CPS® Technology (Complex Perfect Spheres) is a fluid bed rotor technology for producing spherical matrix pellets with a smooth surface and high density. Typically, microcrystalline cellulose is used as a basic excipient for pelletization using the CPS® Technology [1]. In the past extensive studies using soluble APIs (active pharmaceutical ingredient) as Metoprolol succinate [2] and Propranolol hydrochloride [3] were performed. During this study matrix pellets containing an insoluble...