19. April 2018

Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are constructed from (phospho)lipids and (ii) non-biomimetic barriers containing dialysis membranes. This...

16. March 2018

Sex-related differences in drug pharmacokinetics, especially regarding absorption and metabolism, are in part caused by a differential expression and/or activity of membrane transporters between males and females (Soldin and Mattison, 2009, Morris et al., 2013). Certain transporters are known to be influenced by formerly considered “inert” pharmaceutical excipients with which drugs are co-formulated.

17. January 2018

Controlled release dosage forms are essential in certain dosage regimens where release rate of drug impacts the effectiveness for therapy. In the present study, modified release dosage form of Domperidone was developed in the form of pellets which were subsequently compressed into tablet to disintegrate and swallow by patients without changing the release profile.