Posts tagged with "Paediatric formulations"


Graphic which show the hot melt extrusion process and the analysis steps for taste masking
22. February 2018

Solid state characterisation and taste masking efficiency evaluation of polymer based extrudates of isoniazid for paediatric administration

Hot melt extrusion has gained considerable attention as a novel technique for taste masking of bitter APIs. The aim of this study was to investigate whether hot melt extrusion could be used to develop taste masked formulations of isoniazid and also to evaluate and correlate different taste assessment methods Two polymers with different physico-chemical properties, Soluplus and Eudragit E-PO were chosen as carriers for the drug. Eudragit E-PO has already been widely used for taste masking due to...

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09. July 2017

Solid State Characterisation and Taste Masking Efficiency Evaluation of Polymer Based Extrudates of Isoniazid for Paediatric Administration

Hot melt extrusion has gained considerable attention as a novel technique for taste masking of bitter APIs. The aim of this study was to investigate whether hot melt extrusion could be used to develop taste masked formulations of isoniazid and also to evaluate and correlate different taste assessment methods Two polymers with different physico-chemical properties, Soluplus and Eudragit E-PO were chosen as carriers for the drug.

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