13. December 2016

Abstract Partially hydrolysed polyvinyl alcohol (PVA) was evaluated as a pelletisation aid for the production of pellets with a high acetaminophen and metformin hydrochloride concentration (>70%, w/w). Mixtures with varying drug concentration and PVA/microcrystalline cellulose (MCC) ratios were processed via extrusion-spheronisation, either after addition of PVA as a dry powder or as an aqueous solution. Finally, high drug- loaded metformin pellets were coated with a methacrylic acid...

10. June 2015

The application of bad tasting, often bitter APIs to children requires in most cases an effective taste optimisation. This can be achieved either by the addition of flavors or by masking the bad sensation. More