01. September 2018

Pharmaceutical pellets are spherical agglomerates manufactured in extrusion/spheronization process. The composition of the pellets, the amount of active pharmaceutical ingredient (API) and the type of used excipients have an influence on the shape and quality of dosage form. A proper quality of the pellets can also be achieved by identifying the most important technological process parameters. In this paper, a knowledge discovery method, called dominance-based rough set approach (DRSA) has been...

31. August 2018

The main objective of the presented research was to prepare an innovative carrier as a filler for detection tubes in the form of double-coated pellets with a very significant color transition during the detection of cholinesterase inhibitors such as nerve agents, organophosphorus or carbamate insecticides in liquids that is observable visually and also spectrophotometrically at 412 nm. The pellet cores were prepared by the extrusion/spheronization method. Consecutively, two different coats...

18. August 2018

In contrast to classic single-unit dosage forms such as tablets, the dosage of the drug substance in multi-particulate systems is divided on a plurality of subunits – typically consisting of thousands of spherical pellet particles with a diameter of between 100 and 2,000 μm. This means that non-disintegrating, monolithic single-unit forms retain their structure in the digestive tract, whereas the multi-particular preparations consist of numerous sub-units which disperse after administration....

18. August 2018

Older adults with multimorbidity, polypharmacy, and complex health needs are the major consumer of health care. Ensuring that medicines are used safely, effectively, and delivered efficiently in this population is challenging. In this context, the approach to medicines delivery should seek to overcome some of the difficulties of delivering medicines to older people, and ensure each medication is delivered by the optimal and most convenient route for the patient in question. However, this poses...

08. August 2018

The main purpose of this study was to investigate the influence of ethylcellulose (EC) coating and curing conditions on the quality attributes of pharmaceutical pellets prepared using a quality by design (QbD) approach. The drug release rate of methimazole, a freely soluble model drug, was evaluated extensively together with the mechanical strength and true density of the coated pellets. Moreover, the thermal and spectroscopic properties, as well as the surface characteristics were studied...

06. August 2018

Spherical pellets for pharmaceutical applications are widely produced by an extrusion-spheronization process. To achieve an equal, spherical pellet shape with a spheronization process, it is crucial that all pellets are exposed to similar stress conditions. However, in a spheronizer the pellets close to the friction plate are subjected to much higher stresses than pellets at the top of the torus, resulting in a strongly inhomogeneous stress distribution within the particle bed. Therefore, the...

26. July 2018

Paediatric specific medicines have become increasingly researched since the introduction of paediatric investigation plan requirements in 2007. Various dosage forms continue to be investigated for their appropriateness for children, including multiparticulates. Multiparticulates are currently available as tablets, capsules, sachets and medicated spoons/straws/syringes. These presentations offer limited dose flexibility with some only providing a singlefixed dose. A device capable of repeated...

26. June 2018

More and more pharmaceutical products are reaching the market as multiparticulate dosage forms, mainly as pellets. The healthcare sector also frequently selects pellets as the optimal marketable form of functional food. As there are quite a number of existing techniques relating to the production of pellets, it is often very difficult for a formulator or marketing manager to make a choice, since every technique claims to be optimal.

10. June 2018

The focus of the OSeeT are enteric coatings (EC) and modified-release (MR) coatings. The characteristics of the coating layer are revealed via OSeeT: Mean coating thickness → progress of coating process Intra-particle and inter-particle coating variability → for quality and homogeneity of the applied coating Roughness → optical quality of the surface The Technology behind OSeeT is Interferometry OCT is based on white light interferometry: – broad bandwidth resulting in low-coherence...

26. April 2018

Are you a manufacturer of raw materials for the food, nutraceutical or pharmaceutical industry and interested to increase your product performance or functionality? Are topics like Dust free Solubility Protection Taste masking Targeted release Particle size Flowability relevant to you or for the life cycle management of your product? Then come to speak with the experts from IPC Process Center @Vitafoods Geneva Stand T167 - May 15-17, 2018. If not attending just drop us an email. Further...