23. February 2018
SOLUTHIN® MD H: A fast-dispersible hydrogenated phospholipid formulation increasing the dissolution of poorly soluble actives in water Hydrogenated phospholipids (PL) from lecithin are natu- ral products useful for pharmaceutical and cosmetic ap- plications. Due to their higher TC than unsaturated phospholipids, hydration of the phospholipids to form liposomal dispersions requires higher temperatures. SOLUTHIN® MD H is a dry mixture of maltodextrin with pre-formed liposomes made from...
02. June 2016
Phospholipid-based formulations provide a key technology to formulate poorly water-soluble drugs. A recent interest has been in using phospholipids with a high content of monoacyl phosphatidylcholine (monoacyl PC) due to its ability to form mixed micelles of mono- and di-acylphospholipids upon aqueous dispersion. The present work focused on binary drug- monoacyl PC systems (at about equimolar ratio) with respect to screening of solid dispersion feasibility. It was tested whether or not a...
06. May 2015
The aim of this study was to examine the efficacy of self-nano phospholipid dispersions (SNPDs) based on Phosal® to improve the oral bioavailability of curcumin (CUR). SNPDs were prepared with Phosal® 53 and Miglyol 812 at different surfactant ratio... http://www.sciencedirect.com/science/article/pii/S0378517315003877 International Journal of PharmaceuticsAvailable online 29 April 2015