10. January 2018
Extended drug delivery offers numerous benefits compared to immediate release dosage form. Membrane coating of immediate release dosage form is an effective means of producing an extended drug delivery system. Polymers when coated alone, have limited ability to form the rate controlling membrane with good mechanical properties.
22. June 2017
Discovery of several poorly water soluble drugs in the past decade has led to the need of developing a novel dosage form which increases the solubility of the drug and improves oral bioavailability.
22. August 2016
Abstract During the formulation of solid dosage forms coating, plasticizers are added to the film forming polymer to improve the mechanical properties of the coating shell of the drug product. For the coating formulation to be successful and in order to produce flexible continuous film, the plasticizer should be compatible with the film forming polymer (i.e. high plasticizer-polymer miscibility in solid dispersion) (McGinity and Felton, 2008). This paper proposes and compares different...
02. May 2016
Introduction: Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties and well-established safety profile; prime requisites considered during the selection of any excipient in formulation development. Areas covered: The individual properties and applications of PEG have been discussed at length in the existing literature. However, guidance on proper selection of PEG grade to cater to one’s purpose is...
30. November 2015
Pharmaceutical solid dosage forms are commonly coated to modify the release of drugs. Due to the disadvantages of coated single-unit dosage forms, such as occurrences of dose dumping and local irritation, coated multi-particulates are preferred. Coated multi-particulates can eventually be filled into capsules or compressed into tablets. The latter is more desirable as unit production costs of tablets are considerably lower and machinery more easily available. More