09. March 2018
The process of mucoadhesion has been widely studied using a wide variety of methods, which are influenced by instrumental variables and experiment design, making the comparison between the results of different studies difficult. The aim of this work was to standardize the conditions of the detachment test and the rheological methods of mucoadhesion assessment for semisolids, and introduce a texture profile analysis (TPA) method.
02. March 2018
The oral cavity is frequently used to administer pharmaceutical drug products. This route of administration is seen as the most accessible for the majority of patients and supports an independent therapy management. For current oral dosage forms under development, the prediction of their unintended mucoadhesive properties and esophageal transit profiles would contribute for future administration safety, as concerns regarding unintended adhesion of solid oral dosage forms (SODF) during oro-esopha
12. June 2017
Anionic polymers were modified with sulfhydryl bearing ligands to evaluate their mucoadhesiveness.
• Mucoadhesion augmented up to 59.23-fold compared to corresponding unmodified polymer.
• Tensile strength, bioadhesion, rotating cylinder and consolidation assay were performed on buccal tissue.