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25. June 2016
Abstract Background Entecavir is an orally administered guanosine nucleoside analog with activity against hepatitis B virus (HBV) polymerase, which is approved for the treatment of chronic hepatitis B (CHB) infection in adults and children ≥2 years old (USA and EU). Objective To develop simplified entecavir dosing recommendations for young children infected with CHB. Methods Data from recent clinical trials were used to develop a population pharmacokinetic (PPK) model, which allowed us to...