22. March 2018
To obtain a reproducible and specification conforming product quality it is mandatory to control the process parameters for granulation and layering or coating. One important parameter for the development of coating and granulation processes in high shear and fluid bed processes is the spraying system [1] e. g. the application of a feasible droplet size coming out of the respective spraying nozzle. Too large droplets could result in oversized granules or in pellets´ agglomeration, whereas too...
12. June 2016
Introduction: Amorphous solid dispersions are considered as one of the most powerful strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical ingredient (API) dispersed at the molecular level in an amorphous polymeric carrier. As the latter component constitutes the largest part of the formulation, its characteristics will contribute to a large extent to the properties and behavior of the solid dispersion. Areas covered: Amorphous polymers are most often used...