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23. January 2017
Abstract This study has investigated the potential use of zein protein from corn as a pharmaceutical excipient for formulation of oral controlled-release matrices. SMCC (silicified microcrystalline cellulose)-Prosolv® 90, SMCC HD-Prosolv® 90 HD, Avicel® PH 102 and Mannitol 60 were evaluated as co-excipients to improve the processability of zein powder. Zein/SMCC-Prosolv® 90 blend had the best flowability and tabletability. Tablets with tramadol hydrochloride, zein and SMCCProsolv® 90 were...
20. April 2015
ABSTRACT The aim of this study was to evaluate the direct compression behaviour of co-processed cassava starch and colloidal silica in the formulation of metronidazole tablets. Cassava starch was extracted from freshly harvested roots of Manihot glaziovii obtained from IITA farms, Shika, Zaria. Subsequently, it was co-processed with colloidal silica at varying ratios (95:5, 96:4, 97:3, 98:2 and 99:1). Preliminary screening was conducted on the five combinations by determining the crushing...