17. October 2016

Abstract The present study focused on the preparation, physico-chemical, and biological characterization of several composite films containing graphene derivatives (graphene oxide or reduced graphene oxide) and curcumin as antioxidant in methylcellulose matrix. The morphostructural properties of the obtained composites were investigated by scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transformed infrared spectroscopy (FTIR), and X-ray powder diffraction (XRD). The...

08. December 2015

Highlights • Geldart group C ibuprofen particles were silica dry coated to enable fluidization. • Aeration testing and flow function coefficient were indicative of fluidizability. • Dry coated ibuprofen powders could be fluidized and polymer film coated. • Polymer suspensions with stabilized colloidal silica led to reduced agglomeration. • Scalable coating conditions were determined for the micronized ibuprofen powders. More

06. September 2015

Objective of this work was to understand the mechanism of formation of celecoxib nanocrystals in celecoxib: mannitol nanocrystalline solid dispersion (NSD). Solution of celecoxib and mannitol was spray dried in 1:1 (g:g) proportion to obtain NSD, with average crystallite size of 214.07 ± 45.27 nm. Solubility parameters of celecoxib and mannitol were 23.1 MPa1/2 and 38.5 MPa1/2, respectively, hinting their immiscibility. More