05. February 2017

Abstract In this study, electrostatic charging of lactose and its mixtures with salbutamol sulphate (SS) were studied as a function of relative humidity (RH). Powder adhesion onto a steel pipe surface was also investigated. The powders were charged by sliding in a steel pipe. Increase in RH decreased the charging of lactose and mixtures, but the effect on SS was not evident. Furthermore, the charge of the mixtures reversed from negative to positive as RH was increased and remained positive as...

22. November 2016

Abstract Crospovidone is a commonly used tablet disintegrant. However, the synthetic disintegrant has been known to be hygroscopic and high moisture content in crospovidone used could exert deleterious effects on tablets formulated with it. The objective of this study was to elicit a better understanding between crospovidone-water interaction and its effect on disintegrant performance. Moisture sorption and desorption isotherms were obtained together with the enthalpy of immersion. Crospovidone...

22. September 2016

Surface energies and dynamic vapour sorption (DVS) plays an imparative role in drug polymer interaction in the formulation development for a number of applications. Powdered films of two pH sensitive polymers namely hypromellose phthalate (HPMCP) and methacrylic acid copolymer NF (Eudragit L30-55) were studied for surface energy analysis employing inverse-phase gas chromatography (IGC) which is a well-known physi- cal technique in acquiring significant information about surfaces of...

14. September 2016

Abstract This study investigated how the inclusion of magnesium oxide (MgO) maintained tablet hardness during storage in an unpackaged state. Tablets were prepared with a range of MgO levels and stored at 40°C with 75% relative humidity for up to 14 d. The hardness of tablets prepared without MgO decreased over time. The amount of added MgO was positively associated with tablet hardness and mass from an early stage during storage. Investigation of the water sorption properties of the tablet...

13. June 2016

The influence of relative humidity in the pan during coating on polymer deposition and film formation was investigated. Four tablet substrates, differing in hydrophobicity, porosity, and surface roughness, were prepared and coated with Eudragit® RS/RL 30 D (8:2 ratio). The spray rate and atomization air pressure were varied to create two distinct micro-environmental conditions in the coating pan. PyroButton data logging devices placed directly in the pan were found to more accurately reflect...

08. March 2016

In the pharmaceutical tablet film coating process, we clarified that a difference in exhaust air relative humidity can be used to detect differences in process parameters values, the relative humidity of exhaust air was different under different atmospheric air humidity conditions even though all setting values of the manufacturing process parameters were the same, and the water content of tablets was correlated with the exhaust air relative humidity. Based on this experimental data, the...

19. September 2015

30. June 2015

Amorphous formulations of APIs in polymers tend to absorb water from the atmosphere. This absorption of water can induce API recrystallization, leading to reduced long-term stability during storage. In this work, the phase behavior of different formulations was investigated as a function of relative humidity. Indomethacin and naproxen were chosen as model APIs and poly(vinyl pyrrolidone) (PVP) and poly(vinyl pyrrolidone-co-vinyl acetate) (PVPVA64) as excipients. More