21. August 2018
Small granular starches from rice, quinoa and amaranth were modified with octenyl succinic anhydride (OSA) at 5 defined intervals (0 to 3.0%) and investigated with respect to emulsifying capacity and stability. Starch granules’ surface were characterized by Brunauer–Emmett–Teller and contact angle measurements. Emulsifying capacity was characterized by multiple light scattering (MLS) and particle size analysis. Stability towards environmental stress was characterized by centrifugation and...
27. March 2016
Nimesulide microspheres were prepared by the quasi-emulsion solvent diffusion method, using acetylated starches of the indigenous Ofada rice (Oryza glaberrima Steud) with degrees of substitution (DS) 1.42 and 2.62. A full 23 factorial experimental design was performed using DS (X1), drug:polymer ratio (X2) and polymer concentration (X3) as independent factors; size, entrapment, swelling and time taken for 80% drug release (t80) were the dependent variables. Contour plots were generated and data...
12. November 2015
The aim of current research was to develop and characterize solid self-emulsified nanostructures (S-SEN) loaded with a BCS class II drug, Lercanidipine hydrochloride (LCH). The liquid self-emulsified nanostructures (L-SEN) were prepared using rice bran oil and glyceryl monooleate (GMO) as oil phase and Tween 80 and propionic acid as surfactant and co-surfactant respectively. More