04. April 2017

Abstract Ibuprofen is an oral analgesic usually processed by wet granulation. In this manuscript a new roller compaction process for ibuprofen is reported. The low melting point of ibuprofen is a critical point to be considered during processing. Melting of ibuprofen and its posterior solidification leads to a lower soluble form. The hypothesis of this work is that crystallinity of ibuprofen may be a good indicator of the quality for both raw material selection and the granules obtained during...

16. December 2016

Introduction Roller compaction is commonly used in the pharmaceutical industry to improve powder flow and compositional uniformity. The process produces ribbons which are milled into granules. The ribbon solid fraction (SF) can affect both the granule size and the tensile strength of downstream tablets. Roll force, which is directly related to the applied stress on the powder in the nip region, is typically the most dominant process parameter controlling the ribbon solid fraction. This work is...

25. June 2016

Abstract Solvent-free hot-melt coating processing is a novel and cost-efficient approach to manufacturing taste-masked multiparticulate systems. However, most API powders are fine and cohesive and not processable by hot-melt coating. The aim of this study was to produce dense and abrasion-resistant granules with high drug content ( > 80%) via roller compaction for hot-melt coating process optimization. The selected API was ibuprofen sodium dihydrate, a salt of ibuprofen with improved...

11. January 2015