02. May 2018
An increase in the proportion of poorly aqueous soluble drugs that exhibit problems in oral bioavailability is one of the major problems in formulation development. Formulation of lipid-based nanocarriers, such as self-nanoemulsifying drug delivery systems (SNEDDS) and self-microemulsifying drug delivery systems (SMEDDS) have received a lot of attention in recent years as an approach for overcoming poor solubility and oral bioavailability of drugs. SNEDDS are isotropic mixtures of oil,...
18. October 2017
The development of self-nanoemulsifying drug delivery systems (SNEDDS) to enhance the oral bioavailability of lipophilic drugs, is usually based on traditional one-factor-at-a-time approaches.
20. March 2016
This study aims to develop a self-nanoemulsifying drug delivery system (SNEDDS) based on non-ionic surfactant mixtures to improve the oral bioavailability of efavirenz (EFZ) categorized as a class II according to the BCS, for HIV- therapy. The result of solubility studies of EFZ in various excipients utilized for construction of the pseudo ternary phase diagram containing surfactant mixtures. Surfactants in 1:1 combination are used with different co-surfactants in different ratio to delineate...
26. May 2015
The present work focusses on the formulation development and evaluation of functional excipient (surfactant stabilizer), Vitamin E TPGS loaded self-nanoemulsifying drug delivery system (SNEDDS) for improving deliverability and safety profile of Cyclosporine A (CyA)…. Sanyog Jain, Sindhu Kambam, Kaushik Thanki and Amit K Jain RSC Adv., 2015, Accepted Manuscript DOI: 10.1039/C5RA04762E Received 18 Mar 2015, Accepted 20 May 2015 First published online 20 May 2015...
20. May 2015
The objective of the present study was to prepare solid self-nanoemulsifying drug delivery system (S-SNEDDS) containing Capryol-90 as oil phase for the delivery of Embelin, a poorly water soluble herbal active ingredient... http://www.sciencedirect.com/science/article/pii/S1818087615000410