28. September 2016

Abstract Lipid nanoparticles and their multiple designs have been considered appealing nanocarrier systems. Bringing the benefits of these nanosystems together with conventional coating technology clearly results in product differentiation.This work aimed at developing an innovative solid dosage form for oral administration based on tableting nanostructured lipid carriers (NLC), coated with conventional polymer agents. NLC dispersions co-encapsulating olanzapine and simvastatin (Combo-NLC) were...

29. August 2016

Introduction Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance where it has established its place in the broad spectrum of manufacturing operations and pharmaceutical formulation development. HME has been demonstrated as a robust, novel technique to make solid dispersions in order to provide 1.) time-controlled, 2.) modified, 3.) extended, or 4.) targeted drug delivery, resulting in improved bioavailability as well as taste masking...

28. May 2016

Microscale freeze-drying makes rapid process cycles possible for early-stage formulation development. To investigate the effects of equipment scale and cooling rate on the solid state properties and the protein’s secondary structure of a sample, three binary formulations of catalase were prepared and freeze-dried with sucrose, mannitol, or (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD). The protein’s secondary structure was assessed using attenuated total reflection Fourier transform infrared...

01. February 2016

Cutting the costs of tablet manufacture is one of the many advantages melt crystallization offers compared to conventional tableting procedure as a technology for producing pharmaceutical coated tablets. Other advantages include the lower number of steps needed for production, which increases productivity; the lower energy and workforce requirements; and the decreased need for stricter post-production quality control measures while maintaining quality. The scientific term for maintaining...

03. November 2015

How to Scale-Up a Wet Granulation End Point Scientifically provides a single-source devoted to all relevant information on the scale-up of a wet granulation end point. Contents include a general description, problem identification, and theoretical background with supporting literature, case studies, potential solutions, and more. By outlining issues related to scale-up and end-point determination, and then using practical examples and advice to address these issues, How to Scale-Up a Wet...