24. September 2017

Abstract Thermoresponsive polymers are a class of smart materials that exhibit change in their physical properties with temperature, which make them unique and useful materials in a wide range of biomedical applications. Soluplus®, a thermoresponsive block graft copolymer with poly(vinyl acetate) PVAc and poly(vinyl caprolactam) PVCL block grafted on a poly(ethelyne glycol) PEG backbone in a ratio of 30:57:13 respectively, is marketed by BASF Corporation, it aids in solubilizing and increasing...

14. September 2016

Abstract The objective of present study was to explore the application of Soluplus® as a stabilizer for the preparation of febuxostat (FEB) nanocrystals using ball milling technique. Preliminary trials were performed for the selection of stabilizer from HPMC VLV, PVA, PVP K30, Poloxamer 188 and Soluplus®. Soluplus® stabilized FEB nanocrystals were found stable and had least particle size as compared to the batches prepared using other stabilizers. A systematic optimization of critical...

08. February 2016

The difficulty to find a relevant in vitro dissolution test to evaluate poorly soluble drugs is a well-known issue. One way to enhance their aqueous solubility is to formulate them as amorphous solid dispersions. In this study, three formulations containing itraconazole (ITZ), a model drug, were tested in seven different conditions (different USP apparatuses and different media). Two of the formulations were amorphous solid dispersions namely Sporanox®, the marketed product, and extrudates...

20. November 2015

The objective of this study was to evaluate a novel blend of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol 6000 grafted copolymer (Soluplus®) and polyethylene glycol (PEG) 4000 for solubility enhancement, physicochemical stability and anti-diabetic efficacy of the produced solid dispersions containing glimepiride, a biopharmaceutics classification system (BCS) class II sulphonylurea. More