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18. October 2016
Abstract The objectives of the present study were to develop a controlled-release bilayered tablet of aceclofenac (AFN) 200 mg with dual release and to gain a mechanistic understanding of the enhanced sustained release capability achieved by utilizing a binary mixture of the sustained release materials. Different formulations of the sustained-release layer were formulated by employing hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC) as the major retarding polymers. The in...