14. March 2018

Pharmaceutical spray-freeze drying (SFD) includes a heterogeneous set of technologies with primary applications in apparent solubility enhancement, pulmonary drug delivery, intradermal ballistic administration and delivery of vaccines to the nasal mucosa. The methods comprise of three steps: droplet generation, freezing and sublimation drying, which can be matched to the requirements given by the dosage form and route of administration.

06. July 2017

Utilizing spray-freeze-drying, solid dispersions of Azithromycin-PVA were prepared. The samples were characterized by the dissolution tests, FT-IR, DSC, PXRD and SEM. The dissolution and solubility of SFD-SD samples were significantly increased. The prepared samples can be used for the drug nano-suspensions or inhaled aerosols.