13. September 2016
Abstract The nasal absorption of macromolecules from powder formulations and the effect of sodium carboxymethyl cellulose (CMC-Na) as a pharmaceutical excipient on their absorption were studied. Model macromolecules were fluorescein isothiocyanate-labeled dextran (average molecular weight of 4.4kDa, FD4) and insulin. The plasma concentration of FD4 after application of the powder containing 50% starch (control) was higher than that after application of the solution, and the absorption from 50%...
20. February 2016
Extrusion spheronization is the widely used method by which the pellets are formulated. Pellets have certain advantages in the development of modified release dosage forms, Because of their regular shape and size they are suitable for coating and encapsulation processes, In addition, pellets may sometimes improve the bioavailability, reduce the risk of dose dumping and decrease local irritations in the gastrointestinal tract. Ideal pelletizing aid for this process is MCC as it possesses...