14. August 2016

Abstract A multiple-unit formulation for time-dependent colonic release of insulin was obtained by coating insulin and sodium glycocholate immediate-release minitablets with: i) Methocel® E50, a low-viscosity hydroxypropyl methylcellulose (inner coating); ii) 5:1 w/w Eudragit® NE/Explotab® V17, a mixture of a neutral polymethacrylate with a pore-forming superdisintegrant (intermediate coating); iii) Aqoat® AS, enteric-soluble hydroxypropyl methylcellulose acetate succinate (outer coating)....