16. March 2016
Simethicone is viscous, greyish-white, opalescent preparation used as anti foaming agent to prevent formation of gas in gastro intestinal tract. As per USP, it is a mixture of fully methylated linear siloxane polymers containing repeating units of the formula [–(CH3)2SiO–]n, stabilized with trimethylsiloxy end-blocking units of the formula [(CH3)3 SiO–], and silicon dioxide. It contains not less than 90.5 percent and not more than 99.0 percent of polydimethylsiloxane ([–(CH3)2SiO–]n),...
04. March 2016
Improving the solubility of BCS class 2 drugs is a continuing challenge for the pharmaceutical formulator. Improving solubility could allow for formulations using significantly less active and open the door to new dosage forms and avenues for lifecycle extensions. Creating solid dispersions are a promising way to improve drug solubility. Grace SilSol™6035 has a specifically engineered surface and pore distribution to enable stable amorphous dispersions by solvent deposition. Poorly soluble...
04. March 2016
The main purpose of this study was to increase the solubility of poorly soluble drug by preparing solid dispersions. Nifedipine (poorly water soluble drug), when prepared as solid dispersion showed increased solubility and dissolution rate. Solid dispersions of Nifedipine were prepared by using silsol 6035 as carrier in various proportions 10%, 20% and 30% by solvent loading (solvent droplet addition)method and various grades of silica by co-milling method in ratios of (1:1, 1:2 and 2:1). The...
13. November 2015
Friday, November 27, 2015 at Safran Zunft in Basel 10.00 Morning session organized by IMPAG Registration for morning session by IMPAG 12.15 PharmaLunch organized by SAPhW Registration for PharmaLunch by SAPhW
22. May 2015
W. R. Grace & Co. (NYSE: GRA) announces that its manufacturing facility in Worms, Germany has received good manufacturing practice (GMP) certification from EXCiPACT™, an independent subsidiary of the International Pharmaceutical Excipient Council (IPEC) Foundation. http://investor.grace.com/press-release/business-news/grace-european-facility-receives-gmp-excipient-certification-syloid-fp-s
24. February 2015
Grace Syloid Seminar in Munich/Germany on March, 24th 2015 Participation to the seminar is FREE of charge for registrations before February, 28th 2015. Please contact Edith Drake at edith.drake@grace.com