17. May 2018
Current in vitro disintegration methods for polymeric films are qualitative and introduce significant user bias. The goal of these studies is to develop a novel, quantitative disintegration technique which can be used to characterize polymeric films in vitro. Methods A method was developed using a Texture Analyzer instrument to evaluate film disintegration. Solvent-casted, clinically advanced, anti-HIV, vaginal films as well as marketed vaginal films were used throughout these studies. Method...
02. October 2017
Gattefossé emulsifiers can be used to create exciting range of topical dosage forms with excellent texture and sensorial properties that will delight patients.
26. September 2016
Abstract The synthesis of pectin-silica gels for controlled drug release in gastrointestinal tract (GIT) using low methoxyl (LM) and high methoxy (HM) pectins and tetraethoxysilane (TEOS) as precursor is described. The FTIR spectra of the pectin-silica gels show intense absorption bands at 1246 cm−1 and 802 cm−1 corresponding to the vibrations single bondCsingle bondOsingle bondSisingle bond bonds, which absent in the FTIR spectra of the native pectins that indicate the formation covalent...
07. June 2016
Purpose The design of pediatric formulations is challenging. Solid dosage forms for children have to meet the needs of different ages, e.g. high number of dosing increments and strengths. A modular formulation strategy offering the possibility of rapid prototyping was applied. Different tablet compositions and the resulting tablet characteristics were investigated for dispersible tablets using customized analytical methods. Methods Fluid bed granules were blended with extragranular components,...