06. November 2016

Abstract Solid lipid microparticles (SLM) were produced by produced by a two-step process that, firstly, involved the emulsification of the molten lipid phase in a heated aqueous phase and, secondly, the system cooling. Compritol 888 ATO and Precirol ATO 5, including their mixtures with Miglyol 812 or Witepsol H15 were used as lipid components (10-30% w/w). The average size of the SLM prepared with Compritol and Tween 80 as an emulsifier was 3-7 μm and the influence of lipid concentration and...

09. May 2016

An ultrasound measurement system was employed as a non-destructive method to evaluate its reliability in predicting the tensile strength of tablets and investigate the ben- efits of incorporating it in a continuous line, manufacturing solid dosage forms. Tablets containing lactose, acetaminophen, and magnesium stearate were manufactured contin- uously and in batches. The effect of two processing parameters, compaction force and level of shear strain were examined. Young’s modulus and tensile...

02. December 2015

18. July 2015

Phase-sensitive in situ forming implants (ISFI) are a promising platform for the controlled release of therapeutic agents. The simple manufacturing, ease of placement, and diverse payload capacity make these implants an appealing delivery system for a wide range of applications. More