15. June 2018

Semisolid self-microemulsifying drug delivery system (SMEDDS) with optimized drugloading capacity, stability, dispersibility in aqueous media and invitro drug release profile, was evaluated in vivo regarding effects on pharmacokinetics of acyclovir, an antiviral with low bioavailability (BA) and short half-life (t1/2). Additional goal of this study was evaluation of safety of this semisolid SMEDDS consisted of medium chain length triglycerides (oil) (10% w/w), macrogolglycerol hydroxystearate...