15. January 2018
Polysaccharides are natural polymers, or biopolymers with broad spectrum of applications due to their capability of modifying the solution properties by thickening, gelation, emulsification, stabilization, encapsulation, flocculation, swelling and gel formation.
16. November 2016
Context: Sustained release drug delivery systems are more preferred than the conventional drug delivery systems due to its enhanced bioavailability and patient compliance. Earlier studies reported on glibenclamide (GBCM) were not clear and hence, the step has been taken to explore the sustained release drug delivery system of GBCM. Aims: To evaluate the sustained release microspheres obtained of GBCM. Methods: Microspheres were prepared by ionic gelation method using the polymers like Eudragit...
17. July 2016
Background: Introducing the concept of mucoadhesion in the 1980s, application of mucoadhesive polymers for buccal drug delivery has been the subject of pharmaceutical interest. Aim: The purpose of this study was to modify well-known xanthan in order to remarkably boost its suitability for buccal adhesiveness. Method: Xanthan (X) was chemically modified by covalent binding of L-cysteine (SH) exhibiting sulfhydryl groups on the polymeric backbone via amide bond formation. Cytotoxicity, stability...
26. December 2015
Biopolymers are naturally occurring polymeric biomolecules. They are easily accessible, relatively cheap, can be synthetically altered and biodegradable. Locust bean gum and Xanthan gum is widely used ingredient in drug formulations due to their non interacting behavior with the drug and less toxicity. Microparticle formulations of celecoxib, a COX-2 inhibitor were formulated using Locust bean gum and Xanthan gum. More
09. June 2015
Efficacy of melatonin in treating sleep disorders has been demonstrated in numerous studies. Being with short half-life, melatonin needs to be formulated in extended-release tablets to prevent the fast drop of its plasma concentration. However, try to mimic melatonin natural plasma levels during night time is challenging. In this work, Artificial Neural Networks (ANNs) were used to optimize melatonin release.. More
06. April 2015
Int J Pharm Investig. 2015 Apr-Jun; 5(2): 101–106. doi: 10.4103/2230-973X.153387 Suryadevara Vidyadhara, Reddyvallam Lankapalli Sasidhar, Thalamanchi Balakrishna, and Malapolu Santha Vardhan Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, India Address for correspondence: Dr. S. Vidyadhara, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Chandramoulipuram, Guntur - 522 019, Andhra Pradesh, India....
16. February 2015
Denise F. S. Petri* Article first published online: 16 FEB 2015 DOI: 10.1002/app.42035 http://onlinelibrary.wiley.com/doi/10.1002/app.42035/abstract