12. January 2017

Over the past two decades, the increased use of opioids for legitimate medical purposes has been paralleled by a substantial increase in nonmedical use and abuse of opioids. The numbers are alarming and have risen to epidemic proportions. According to the Centers for Disease Control and Prevention, nearly 2 million Americans abused or were dependent on prescription opioids. Overdose deaths involving prescription opioids have quadrupled since 1999, with 165,000 people dying of overdoses related...

24. November 2016

Misuse and Abuse of Prescription Drugs Prescription pain relievers are safe and effective when used correctly for a medical condition and under a doctor’s supervision. But they can cause serious side effects if not used correctly. Incorrect use or use for non-medical reasons can lead to abuse, addiction and even death1). SAMHSA recently reported results from their 2014 Survey on Drug and Health2). About 4.3 million people age twelve and older reported nonmedical use of prescription pain...

02. August 2016

ABSTRACT Introduction: Many abuse-deterrent formulations (ADFs) rely on being crush resistant and extraction resistant in order to provide deterrence to abuse by insufflation and injection, respectively. High molecular weight polymers such as poly(ethylene oxide) are commonly used to provide this deterrence. However, these polymers suffer from slow dissolution kinetics, and are susceptible to variety of abuse conditions. Objective: This study was aimed to determine if selected superabsorbent...

28. June 2015

Oxycodone DETERx® is an extended-release (ER), microsphere-in-capsule abuse-deterrent-formulation designed to retain its extended-release properties following tampering or misuse (e.g., chewing, crushing). This study assessed the safety and pharmacokinetics of orally administered intact and crushed Oxycodone DETERx® capsules compared with intact and crushed reformulated OxyContin® tablets and crushed immediate-release oxycodone tablets (IR oxycodone). More

05. May 2015

Pernix announced the launch of a new formulation of Zohydro ER (hydrocodone bitartrate extended-release capsules) with BeadTek, a new abuse-deterrent technology... http://www.empr.com/new-zohydro-er-formulation-with-abuse-deterrent-technology-launched/article/412682/

28. January 2015

Jeffrey Fudin, BS, PharmD, DAAPM, FCCP http://www.pharmacytimes.com/contributor/jeffrey-fudin/2015/01/abuse-deterrent-opioid-formulations-purpose-practicality-and-paradigms